![]() ![]() ![]() Subsequently, phages have to penetrate the bacterial cell envelope and will eventually eject their viral genome into the cytoplasm (Weinbauer 2004). Every phage infection is initiated by adsorption (i.e., the attachment of the phage particle to the bacterial host cell), which is characterized by the specific recognition of a receptor located on the bacterial cell surface. In addition, we present methods that can be used for activity determination and the application potential of these enzymes as antibacterials, antivirulence agents, and diagnostic tools.īacteriophages (phages) are bacterial predators. We discuss the existing diversity in structural locations, variable architectures, enzymatic specificities, and evolutionary aspects of polysaccharide depolymerases and virion-associated lysins (VALs) and illustrate how these aspects can correlate with the host spectrum. For that purpose, bacteriophages are equipped with various virion-associated carbohydrate active enzymes, termed polysaccharide depolymerases and lysins, that recognize, bind, and degrade the polysaccharide compounds. The irreversible adherence followed by genome material ejection into host cell cytoplasm must be preceded by the passage of diverse carbohydrate barriers such as capsule polysaccharides (CPSs), O-polysaccharide chains of lipopolysaccharide (LPS) molecules, extracellular polysaccharides (EPSs) forming biofilm matrix, and peptidoglycan (PG) layers. Bacteriophages are bacterial viruses that infect the host after successful receptor recognition and adsorption to the cell surface.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |